Henry reaction is an important reaction employing carbonyls which furnishes β-nitro alcohol,
nitroalkene, α-nitro ketones, β-amino alcohol as products and byproducts that may be transfigured
as building blocks for other synthetic reactions. This paper focuses on various synthetic routes
for Henry reaction, a versatile reaction of high significance in organic synthesis. The paper discusses
the chemistry and plausible products of the reaction, along with the various available synthetic routes
for the same, ranging from classical conventional methods to modern methods of green chemistry
trends. Use of various catalysts as rate enhancer as well as use of various catalysts as enantioselective
frontman for stereoselective reactions, have been described in this work.
Keywords: Carbonyl, henry reaction, nitroaldol reaction, nitroalkene, α-nitro ketones, β-amino alcohol, β-nitro alcohol.
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