Synthesis and Biological Potentials of Quinoline Analogues: A Review of Literature

Author(s): Leena Kumari, Salahuddin*, Avijit Mazumder, Daman Pandey, Mohammad Shahar Yar*, Rajnish Kumar, Rupa Mazumder, Mohammad Sarafroz, Mohamed Jawed Ahsan, Vivek Kumar, Sushma Gupta.

Journal Name: Mini-Reviews in Organic Chemistry

Volume 16 , Issue 7 , 2019

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Graphical Abstract:


Abstract:

Heterocyclic compounds are well known for their different biological activity. The heterocyclic analogs are the building blocks for synthesis of the pharmaceutical active compounds in the organic chemistry. These derivatives show various type of biological activity like anticancer, antiinflammatory, anti-microbial, anti-convulsant, anti-malarial, anti-hypertensive, etc. From the last decade research showed that the quinoline analogs plays a vital role in the development of newer medicinal active compounds for treating various type of disease. Quinoline reported for their antiviral, anticancer, anti-microbial and anti-inflammatory activity. This review will summarize the various synthetic approaches for synthesis of quinoline derivatives and to check their biological activity. Derivatives of quinoline moiety plays very important role in the development of various types of newer drugs and it can be used as lead compounds for future investigation in the field of drug discovery process.

Keywords: Quinoline, quinoline derivatives, synthetic schemes, Conard-Limpach synthesis, Doebner reaction, Doebner-Miller Reaction Gould-Jacobs reaction, Skraup synthesis.

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VOLUME: 16
ISSUE: 7
Year: 2019
Page: [653 - 688]
Pages: 36
DOI: 10.2174/1570193X16666190213105146
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