Endometrial Regeneration in Asherman's Syndrome: Clinical and Translational evidence of Stem Cell Therapies

Author(s): Xuejing Hou, Ying Liu*, Isabelle Streuli, Patrick Dällenbach, Jean Dubuisson, Yveline Ansaldi, Nicola Pluchino*.

Journal Name: Current Stem Cell Research & Therapy

Volume 14 , Issue 6 , 2019

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Abstract:

Asherman’s Syndrome or Intrauterine adhesions is an acquired uterine condition where fibrous scarring forms within the uterine cavity, resulting in reduced menstrual flow, pelvic pain and infertility. Until recently, the molecular mechanisms leading to the formation of fibrosis were poorly understood, and the treatment of Asherman’s syndrome has largely focused on hysteroscopic resection of adhesions, hormonal therapy, and physical barriers. Numerous studies have begun exploring the molecular mechanisms behind the fibrotic process underlying Asherman’s Syndrome as well as the role of stem cells in the regeneration of the endometrium as a treatment modality. The present review offers a summary of available stem cell-based regeneration studies, as well as highlighting current gaps in research.

Keywords: Endometrium, Asherman's syndrome, intrauterine adhesions, stem cells, scaffold, human embryonic stem cells.

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Article Details

VOLUME: 14
ISSUE: 6
Year: 2019
Page: [454 - 459]
Pages: 6
DOI: 10.2174/1574888X14666190213100528
Price: $58

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