Modular Synthesis of New Bicyclic Carbene Precursors

Author(s): Jie Li, Jiaqi Yao, Weiping He, Fan Yang, Xiaoming Liu*.

Journal Name: Letters in Organic Chemistry

Volume 16 , Issue 12 , 2019

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Abstract:

A series of new N-heterocyclic carbene (NHC) precursors, containing bicyclic pyrrolo[1,2- c]imidazole framework, were prepared from N-(tert-butoxycarbonyl)-L-proline (1-Boc-L-proline). The sequential attachment of nitrogen nucleophiles and subsequent ring closure gave the desired bicyclic NHC precursors in good yields. The structures of these new NHC precursors were determined on the basis of spectroscopic techniques, including NMR and MS.

Keywords: N-heterocyclic carbene, proline, synthesis, chirality, nitrogen nucleophiles, precursors.

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Article Details

VOLUME: 16
ISSUE: 12
Year: 2019
Page: [951 - 954]
Pages: 4
DOI: 10.2174/1570178616666190212125426
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