Drug/Vehicle Impacts and Formulation Centered Stratagems for Enhanced Transdermal Drug Permeation, Controlled Release and Safety: Unparalleled Past and Recent Innovations-An Overview

Author(s): Balamurugan Manickam*, Rajesh Sreedharan, Kumarappan Chidambaram.

Journal Name: Current Drug Therapy

Volume 14 , Issue 3 , 2019

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Graphical Abstract:


Abstract:

Transdermal drug delivery systems (TDDS) are one of the fascinating unconventional drug delivery systems offering plentiful advantages of which patient compliance is of paramount importance. However, as a matter of fact, the transdermal delivery of drug molecules is absolutely a tedious job which is precisely influenced by a number of factors including penetration barrier properties of the skin, drug characteristics formulation allied issues, etc. Over the years, innumerable tremendous efforts have been made in transporting the drugs through the skin into the systemic circulation by noteworthy tactics. This paper discusses such revolutionary formulation based techniques that have been endeavored in achieving the enhanced skin permeation of drugs, controlled release, and safety.

Keywords: Formulation strategies, drug and vehicle impacts, transdermal drug delivery, enhanced drug permeation, controlled release, safety.

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Article Details

VOLUME: 14
ISSUE: 3
Year: 2019
Page: [192 - 209]
Pages: 18
DOI: 10.2174/1574885514666190212113754
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