Impact of the Fontan Operation on Organ Systems

Author(s): Miriam Michel*, Manuela Zlamy, Andreas Entenmann, Karin Pichler, Sabine Scholl-Bürgi, Daniela Karall, Ralf Geiger, Christina Salvador, Christian Niederwanger, Hideo Ohuchi.

Journal Name: Cardiovascular & Hematological Disorders-Drug Targets
(Formerly Current Drug Targets - Cardiovascular & Hematological Disorders)

Volume 19 , Issue 3 , 2019

Become EABM
Become Reviewer

Graphical Abstract:


In patients having undergone the Fontan operation, besides the well discussed changes in the cardiac, pulmonary and gastrointestinal system, alterations of further organ systems including the hematologic, immunologic, endocrinological and metabolic are reported. As a medical adjunct to Fontan surgery, the systematic study of the central role of the liver as a metabolizing and synthesizing organ should allow for a better understanding of the pathomechanism underlying the typical problems in Fontan patients, and in this context, the profiling of endocrinological and metabolic patterns might offer a tool for the optimization of Fontan follow-up, targeted monitoring and specific adjunct treatment.

Keywords: Endocrinology, follow-up, fontan, gastroenterology, hepatology, hematology, immunology, metabolism.

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Article Details

Year: 2019
Page: [205 - 214]
Pages: 10
DOI: 10.2174/1871529X19666190211165124
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