Preparation and Evaluation of Chitosan Loaded Naproxen Nanoparticles by Emulsion Interfacial Reaction Method

Author(s): Abbaraju Krishna Sailaja* , Juveria Banu .

Journal Name: Drug Delivery Letters

Volume 9 , Issue 2 , 2019

Become EABM
Become Reviewer

Graphical Abstract:


Abstract:

Aim: The aim of this investigation was to develop and characterize naproxen loaded chitosan nanoparticles by emulsion interfacial reaction method.

Methodology: For emulsion interfacial reaction method chitosan was used as a polymer. In this method, eight formulations were prepared by varying drug to polymer concentration.

Discussion: Out of eight formulations prepared using emulsion interfacial reaction method EI8 formulation was found to be the best formulation. The drug content was observed as 94.4%, entrapment efficiency and loading capacity were found to be 87.5% and 75%, respectively. The mean particle diameter was measured as 324.6nm and the Zeta potential value was found to be -42.4mv. In vitro drug release data showed 97.2% of drug release rate sustained up to 12hrs.

Conclusion: The results clearly reveal that EI8 formulation having the highest amount of drug was considered as the best formulation because of its small mean particle diameter, good entrapment efficiency, and stability.

Keywords: Zeta potential, mean particle diameter, drug content, entrapment efficiency, chitosn, emulsion interfacial reaction method, loading capacity, drug release studies.

[1]
Sailaja, K.A.; Sreelola, V. Preparation and characterization of diltiazem HCl loaded bovine serum albumin nanoparticles by desolvation technique. Pharm. Nanotechnol., 2016, 4(4), 308-315.
[2]
Sailaja, A.K.; Amareshwar, P.; Chakravarty, P. Different techniques for the preparation of nanoparticles using natural polymers and their applications. Int. J. Pharm. Pharm. Sci., 2011, 3(2), 45-50.
[3]
Jahangirian, Hossein A review of drug delivery systems based on nanotechnology and green chemistry: Green nanomedicine. Int. J. Nanomedicine, 2017, 12, 2957-2978.
[4]
Garud, A.; Singh, D.; Garud, N. Solid lipid nanoparticles (Sln): Method, characterization and applications. Int. Curr. Pharm. J., 2012, 1(11), 384-393.
[5]
Kumar, C.S.S.R.; Mohammad, F. Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery. Adv. Drug Deliv. Rev., 2011, 63(9), 789-808.
[6]
Chan, Li. Development and validation of a method for determination of encapsulation efficiency of CPT-11/ DSPE-mPEG2000 nanoparticles. Med. Chem., 2016, 6, 345.
[7]
Duxfield, L.; Sultana, R.; Wang, R.; Englebretsen, V.; Deo, S.; Swift, S.; Rupenthal, I.; Al-Kassas, R. Development of gatifloxacin-loaded cationic polymeric nanoparticles for ocular drug delivery. Pharm. Dev. Technol., 2012, 21(2), 172-179.
[8]
Yang, F.; Liang, D.; Long, Jiang. F.; Xing Ni, Q. Magnetic lymphatic targeting drug delivery system using carbon nanotubes. Med. Hypotheses, 2008, 70(4), 765-767.
[9]
Goyal, K.; Koul, V.; Singh, Y.; Anand, A. Targeted drug delivery to central nervous system (CNS) for the treatment of neurodegenerative disorders: Trends and advances. Cent. Nerv. Syst. Agents Med. Chem., 2014, 14(1), 43-59.
[10]
Grau, M.J.; Kayser, O.; Muller, R.H. Nanosuspensions of poorly soluble drugs reproducibility of small-scale production. Int. J. Pharm., 2000, 196, 155-157.
[11]
Haijuan, K.; Deng, H.; Lei, Z. Preparation and characterization of hollow Fe3O4/SiO2 PEG-PLA nanoparticles for drug delivery. Engineering, 2013, 194-199.
[12]
Heidari, A. Pharmaceutical and analytical chemistry study of cadmium oxide (CdO) nanoparticles synthesis methods and properties as anti-cancer drug and its effect on human cancer cells. Pharm. Anal. Chem., 2016, 2, 113.
[13]
McInnes, I.B.; Schett, G. Mechanisms of disease, the pathogenesis of rheumatoid arthritis. N. Engl. J. Med., 2011, 4(8), 461-473.
[14]
Javadzadeh, Y.; Ahadi, F.; Davaran, S.; Mohammadi, G.; Sabzevari, A.; Adibkia, K. Preparation and physicochemical characterization of naproxen-plga nanoparticles. Colloids Surf. B Biointerfaces, 2010, 498-502.
[15]
Jawahar, N.; Meyyanathan, S.N. Polymeric nanoparticles for drug delivery and targeting: A comprehensive review. Int. J. Health Allied Sci., 2012, 1, 217-223.
[16]
Govan, J. Gun ko, Y.K. Recent advances in the application of magnetic nanoparticles as a support for homogeneous catalysts. Nanomaterials (Basel), 2014, 4(2), 222-241.
[17]
Kayser, O. Nanosuspensions for the formulation of aphidicolin to improve drug targeting effects against Leishmania infected macrophages. Int. J. Pharm., 2000, 196, 253-256.
[18]
Khan, K.; Rehman, S.; Rahman, H.U.; Khan, Q. Synthesis and application of magnetic nanoparticles. Nanomagnetism, 2011, 1, 136-153.
[19]
Ranjeet, K.; Baqee, A.A. Nanoparticle: An overview of preparation, characterization and applications. Int. Res. J. Pharm., 2013, 4(4), 47-57.
[20]
Breunig, M.; Bauer, S.; Goepferich, A. Polymers and nanoparticles: Intelligent tools for intracellular targeting. Eur. J. Pharm. Biopharm., 2008, 68(1), 112-128.
[21]
Dadwal, M. Polymeric nanoparticles as promising novel carriers for drug delivery: An overview. J. Adv. Pharm. Educ. Res., 2014, 4(1), 20-30.


Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 9
ISSUE: 2
Year: 2019
Page: [89 - 96]
Pages: 8
DOI: 10.2174/2210303109666190211150117
Price: $58

Article Metrics

PDF: 21
HTML: 3