The failure of the Integrase Strand Transfer Inhibitors (INSTIs) due to the mutations occurring
at the catalytic site of HIV integrase (IN) has led to the design of allosteric integrase inhibitors
(ALLINIs). Lens epithelium derived growth factor (LEDGF/p75) is the host cellular cofactor which
helps chaining IN to the chromatin. The protein-protein interactions (PPIs) were observed at the
allosteric site (LEDGF/p75 binding domain) between LEDGF/p75 of the host cell and IN of virus. In
recent years, many small molecules such as CX04328, CHIBA-3053 and CHI-104 have been reported as
LEDGF/p75-IN interaction inhibitors (LEDGINs). LEDGINs have emerged as promising therapeutics to
halt the PPIs by binding at the interface of both the proteins. In the present work, we correlated the
docking scores for the reported LEDGINs containing quinoline scaffold with the in vitro biological data.
The hierarchal clustering method was used to divide the compounds into test and training set. The robustness
of the generated model was validated by q2 and r2 for the predicted set of compounds. The
generated model between the docking score and biological data was assessed to predict the activity of
the hits (quinoline scaffold) obtained from virtual screening of LEDGINs providing their structureactivity
relationships to aim for the generation of potent agents.
Keywords: HIV/AIDS, Integrase, LEDGF/p75, Allosteric, Quinoline, INSTIs.
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