Role of Seminal Plasma Proteins in Effective Zygote Formation- A Success Road to Pregnancy

Author(s): Archana Kumar, T.B. Sridharn*, Kamini A. Rao.

Journal Name: Protein & Peptide Letters

Volume 26 , Issue 4 , 2019

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Graphical Abstract:


Abstract:

Seminal plasma proteins contributed by secretions of accessory glands plays a copious role in fertilization. Their role is overlooked for decades and even now, as Artificial Reproduction Techniques (ART) excludes the plasma components in the procedures. Recent evidences suggest the importance of these proteins starting from imparting fertility status to men, fertilization and till successful implantation of the conceptus in the female uterus. Seminal plasma is rich in diverse proteins, but a major part of the seminal plasma is constituted by very lesser number of proteins. This makes isolation and further research on non abundant protein a tough task. With the advent of much advanced proteomic techniques and bio informatics tools, studying the protein component of seminal plasma has become easy and promising. This review is focused on the role of seminal plasma proteins on various walks of fertilization process and thus, the possible exploitation of seminal plasma proteins for understanding the etiology of male related infertility issues. In addition, a compilation of seminal plasma proteins and their functions has been done.

Keywords: Male infertility, seminar plasma, artificial reproduction techniques, accessory reproductive glands, immunomodulatory seminal proteins, fertilization.

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VOLUME: 26
ISSUE: 4
Year: 2019
Page: [238 - 250]
Pages: 13
DOI: 10.2174/0929866526666190208112152
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