In the last decades, bioengineers have developed myriad biomaterials for regenerative medicine. Development
of screening techniques is essential for understanding complex behavior of cells in the biological microenvironments.
Conventional approaches to the screening of cellular behavior in vitro have limitations in terms
of accuracy, reusability, labor-intensive screening, and versatility. Thus, drug screening and toxicology test
through in vitro screening platforms have been underwhelming. Recent advances in the high-throughput screening
platforms somewhat overcome the limitations of in vitro screening platforms via repopulating human tissues’
biophysical and biomchemical microenvironments with the ability to continuous monitoring of miniaturized
human tissue behavior. Herein, we review current trends in the screening platform in which a high-throughput
system composed of engineered microarray devices is developed to investigate cell-biomaterial interaction. Furthermore,
diverse methods to achieve continuous monitoring of cell behavior via developments of biosensor
integrated high-throughput platforms, and future perspectives on high-throughput screening will be provided.
Keywords: High-throughput platforms, cell-biomaterial interactions, cellular microenvironments, biomaterial screening, organs-on-a-chip,
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