The Gut Microbiome, Lactobacillus acidophilus; Relation with Type 2 Diabetes Mellitus

Author(s): Mohamed R. Halawa, Mouchira Abd El-Salam, Bassem M. Mostafa*, Salma S. Sallout.

Journal Name: Current Diabetes Reviews

Volume 15 , Issue 6 , 2019

Become EABM
Become Reviewer

Abstract:

Background: Symbiotic interactions of microorganisms are widespread in nature, and support fundamentally important processes linking health and disease to the bacterial ecology. Intestinal microbiota is the largest source of microbial stimulation that exerts both harmful and beneficial effects on human health. It participates in the development of the postnatal immune system as well as oral tolerance and immunity. The recently explored impact of the microbiota on energy metabolism, gut hormone regulation and the gut-brain axis was judged to be a fascinating topic and of great value in the future, and can have a clinical role in the management of obesity and diabetes.

Objective: To assess the impact of the gut microbe, Lactobacillus acidophilus, in patients with type 2 Diabetes Mellitus (controlled and uncontrolled) compared to healthy individuals, as a preliminary approach to future treatment with probiotics, prebiotics or diet modulation.

Methods: A case control study was conducted on 30 diabetic patients and 10 control individuals. All patients were subjected to full history, thorough clinical examination, and laboratory measurement of fasting blood sugar, 2 hours post prandial, Glycosylated Hemoglobin (HbA1C), CRP (C-Reactive Protein), Lipid profile, and Identification of stool Lactobacillus acidophilus by PCR (polymerase chain reaction) technique.

Results: Significantly lower Stool Lactobacillus acidophilus PCR count among diabetic patients when compared to healthy control individuals.

Conclusion: Stool Lactobacillus acidophilus PCR count was lower among type 2 diabetic patients, which may show relationship of lactobacillus with type 2 diabetes mellitus. However, further studies are needed to determine correlation or causation of this relationship.

Keywords: Gut microbiome, diabetes mellitus, Lactobacillus acidophilus, probiotic, prebiotic, polymerase chain reaction.

[1]
Ali F, Ashour Z, Shahin R, et al. Role of intestinal microflora (Lactobacillus acidophilus) in phagocytic function of leukocytes in type 2 diabetic patients. Egyptian J Med Human Genet 2012; 14(1): 95.
[2]
American Diabetes Association (ADA). Standards of Medical Care in Diabetes 2015; 38(1): S31-48.
[3]
Burcelin R, Serino M, Chabo C, Blasco-Baque V, Amar J. Gut microbiota and diabetes: From pathogenesis to therapeutic perspective. Acta Diabetol 2011; 48(4): 257-73.
[4]
Gomes A, Bueno A, de Souza R, Mota J. Gut microbiota, probiotics and diabetes. Nutr J 2014; 13(1): 60.
[5]
International Diabetes federation. Middle East and North Africa. Egypt Available at:. https://www.idf.org/our-network/regions-members/middle-east-and-north-africa/members/34-egypt.html Accessed June 2017.
[6]
Khan MT, Nieuwdorp M, Bäckhed F. Microbial modulation of Insulin sensitivity. Cell Metab 2014; 20(5): 753-60.
[7]
Lancet T. Diabetes: An ounce of prevention is worth a pound of cure. Lancet (London, England) 2015; 386(9997): 932.
[8]
Larsen N, Vogensen F, van den Berg F, et al. Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults. PLoS One 2010; 5(2): e9085-9.
[9]
Qin J, Li Y, Cai Z, et al. A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 2012; 490(7418): 55-60.
[10]
Tilg H, Moschen A. Microbiota and diabetes: An evolving relationship. Gut 2014; 63(9): 1513-21.


Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 15
ISSUE: 6
Year: 2019
Page: [480 - 485]
Pages: 6
DOI: 10.2174/1573399815666190206162143
Price: $65

Article Metrics

PDF: 49
HTML: 2
EPUB: 2
PRC: 1