Metronidazole, a widely used antibacterial and antiprotozoal drug, is often the drug of
choice in amoebic liver abscess. The drug, otherwise safe, can cause serious central nervous disturbances
in rare circumstances. Here, we report a case of cerebellar dysfunction in the form of slurring
of speech and episodes of falls, in an elderly male following a three-week course of metronidazole
therapy. The patient manifested classic radiologic features of metronidazole neurotoxicity.
Marked improvement in clinical symptoms was seen following drug discontinuation.
Keywords: Nitro imidazole, pharmacovigilance, pharmacogenetics, neurotoxicity and amoebiasis.
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