Relationship Between Level of Heart Type Fatty Acid Binding Protein (Before and after Procedures) with Acute Renal Failure after PCI in Patients Under PCI

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Author(s): Mina Mohammadzadeh, Habib Haybar*, Ahmad Reza Assare, Zeinab Deris Zayeri, Shahla Assadi Hoveyzian.

Journal Name: Cardiovascular & Hematological Disorders-Drug Targets
(Formerly Current Drug Targets - Cardiovascular & Hematological Disorders)

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Background & Objective: Acute renal failure (AKI) is one of the most important complications of PCI. Due to delay in creatinine increase, we need specific factors to detect AKI earlier. The aim of this study is to evaluate the valuable factors with a focus on (HFAB-P) that can be predictive for AKI after Percutaneous Coronary Intervention (PCI).

Methods: This prospective study was performed on 95 patients (55 males and 44 females aged between 49-78 years) under PCI in Golestan and Imam Khomeini hospitals in Ahvaz. Patients were divided into three groups based on the development of AKI after procedure: no AKI, severe AKI (doubling of serum creatinine or needing dialysis) and any type of AKI (increased creatinine ≥ 0/3 mg/dl or a 50% increase in the means of 1/5 times serum creatinine). The demographic and clinical characteristics of the patients, the medical history and the results of the HFABP marker, GFR, and creatinine before and after PCI were evaluated for all patients.

Results: The progenies showed six patients with severe AKI, 17 patients with any type of AKI, and 72 patients without AKI. Diabetes (P = 0.003), hypertension (P = 0.027), gender of patients (P = 0.025), hospital admission days (P <0.001) were significantly different among the groups. Patients' age and positive troponin were significantly higher in patients with AKI. HFABP was the only factor that had significant changes before and after PCI (P <0.001). HFABP cut off was 4.69 and the sensitivity was defined (95.6%), and the specificity was defined (84.7%) so it has a good negative predictive value of 98.39% which suggests it to be a good test for the AKI prediction. Glomerular Filtration Rate (GFR) and creatinine (Cr) were significantly different after PCI (P <0.001).

Conclusion: HFABP can be considered as a predictor forAKI after PCI. Also, our study suggests that evaluating several parameters such as as Cr and GFR before and after PCI can predict the AKI development after PCI.

Keywords: Acute Kidney Injuries, Coronary Intervention, Percutaneous, H-FABP protein

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(E-pub Ahead of Print)
DOI: 10.2174/1871529X19666190206153012