Background: Cancer is one of most dangerous diseases that seriously threaten human
health, while tumor biomarkers provide important information for clinical diagnosis and treatment of
cancers. Given the low abundance of tumor biomarkers in the bodily fluids at the early stage of cancers,
it is particularly important to develop bio sensing methods for accurate measurement of tumor
biomarkers with high sensitivity.
Objective: Nowadays, gold nanoparticles (AuNPs) that have remarkable physical and chemical properties
are extensively used in the design of biosensing strategies. In this context, we mainly review
the research progress of AuNPs-based biosensing methods for tumor-related biomedical applications
in bodily fluids in recent years.
Results: Optical, electrochemical and mass spectrometric biosensing methods using AuNPs are
widely used for excellent performances in the assay of tumor biomarkers.
Conclusion: The existing methods demonstrate high clinical value, while challenges and expectation
of biosensing method in tumor-related biomedical application are also discussed.