Introduction: Thyroid hormones are essential for the normal development, differentiation,
metabolic balance and physiological function of all tissues. Mean platelet volume (MPV) indicates
mean platelet size and reflects platelet production rate and stimulation. Increased platelet size has been
observed in association with known cardiovascular risk factors. The neutrophil/lymphocyte ratio
(NLR) and platelet/lymphocyte ratio (PLR) are known markers of the systemic inflammatory response.
This study aimed to investigate the effect of thyroid hormone changes by comparing platelet count,
MPV values, NLR and PLR in thyroid papillary carcinoma.
Methods: Forty-nine females and nine males comprising a total of 58 patients were included in the
study. Clinical and laboratory parameters of patients were recorded in the following three phases of the
disease: euthyroid phase (before thyroid surgery), overt hypothyroid (OH) phase (before radioactive
iodine [RAI] treatment) and subclinical hyperthyroid (SCH) phase (six months after RAI treatment).
Results: The mean thyroid-stimulating hormone (TSH) values of the patients in the euthyroid, OH and
SCH phases were 1.62±1.17, 76.4±37.5 and 0.09±0.07 µIU/mL, respectively. The mean MPV values
of the patients in the euthyroid, OH and SCH phases were 9.45±1.33, 9.81±1.35 and 9.96±1.21 fL,
respectively. MPV was significantly higher in the SCH phase than in the euthyroid phase (p=0.013).
Platelet count, NLR and PLR were not statistically different between the euthyroid, OH and SCH
Conclusion: The results of this study demonstrated that the levels of MPV increased significantly in
the SCH phase in patients with papillary thyroid carcinoma (PTC), and increased MPV values contributed
to increased risk of cardiovascular complications. These findings suggest that MPV can be a valuable,
practical parameter for monitoring the haemostatic condition in thyroid disorders. No significant
difference was observed in platelet count, NLR and PLR in all stages of PTC.