Background: Salivary adenoid cystic carcinoma (ACC) is a malignant tumor located at
oral and maxillofacial regions, and its conventional treatments are surgery, chemotherapy and radiotherapy.
However, its poor survival rates and prognosis resulting from the molecular mechanisms
underlying the carcinogenesis remain obscure. To date, there are insufficient reviews to
summarize the genes and molecular pathways for ACC. Therefore, it is required for us to highlight
the main oncogenes, tumor suppressor genes and genetic signal transduction pathways associated
with the ACC in the review.
Methods: A literature review based on PubMed for the genetic characteristics and molecular
transduction pathways about ACC was conducted. Ninety articles were selected as a review of
references using the search terms or keywords such as “genes, molecular pathways, salivary adenoid
cystic carcinoma and ACC”.
Results: We have briefly described histopathology, its current treatments and main clinical features,
besides we elaborated the associated genes and pathways of adenoid cystic carcinoma in this
review according to the searched articles in recent years.
Conclusion: We have summarized vital genes and proteins for targeted and mechanism-based on
proliferation, apoptosis, invasion and metastasis. Although there are few kinds of research on
ACC currently exist, we expect that better detailed genetic studies would pave the way for promising
advancement in our understanding of the molecular biology and pathogenesis mechanisms underlying