Carotid Artery Stenosis (CAS) is a marker of systemic atherosclerosis and patients with
CAS are at high risk of vascular events in multiple vascular locations, including ipsilateral
ischemic stroke. Both medical and surgical therapies have been demonstrated effective in reducing
this risk. The optimal management for patients with asymptomatic carotid artery stenosis remains
controversial. In patients with symptomatic CAS ≥70%, CEA has been demonstrated to reduce the
risk of stroke. With the risk of recurrent stroke being particularly high in the first 2 weeks after the
first event, Carotid Endarterectomy (CEA) or carotid angioplasty with stenting provides maximal
benefits to patients with symptomatic CAS ≥70% if performed within this «2-week» target. Several
large ongoing trials are currently comparing the risks and benefits of carotid revascularization
versus medical therapy alone.
Keywords: Carotid artery stenosis, clinical trials, stroke; cardiovascular risk, prevention, carotid endarterectomy, carotid stenting.
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