Current Medical and Surgical Stroke Prevention Therapies for Patients with Carotid Artery Stenosis

Author(s): Mirza Jusufovic*, Karolina Skagen, Kirsten Krohg-Sørensen, Mona Skjelland.

Journal Name: Current Neurovascular Research

Volume 16 , Issue 1 , 2019

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Abstract:

Carotid Artery Stenosis (CAS) is a marker of systemic atherosclerosis and patients with CAS are at high risk of vascular events in multiple vascular locations, including ipsilateral ischemic stroke. Both medical and surgical therapies have been demonstrated effective in reducing this risk. The optimal management for patients with asymptomatic carotid artery stenosis remains controversial. In patients with symptomatic CAS ≥70%, CEA has been demonstrated to reduce the risk of stroke. With the risk of recurrent stroke being particularly high in the first 2 weeks after the first event, Carotid Endarterectomy (CEA) or carotid angioplasty with stenting provides maximal benefits to patients with symptomatic CAS ≥70% if performed within this «2-week» target. Several large ongoing trials are currently comparing the risks and benefits of carotid revascularization versus medical therapy alone.

Keywords: Carotid artery stenosis, clinical trials, stroke, cardiovascular risk, prevention, carotid endarterectomy, carotid stenting.

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VOLUME: 16
ISSUE: 1
Year: 2019
Page: [96 - 103]
Pages: 8
DOI: 10.2174/1567202616666190131162811
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