Background: Mammary gland tissue (left half) revealed the presence of excess proliferation
of fibrous tissue with disorganization of alveolar structures and the right half showed extensive
fibrous tissue proliferation of mammary gland following intramammary inoculation of 2000 c.f.u. of
Staphylococcus aureus. However, oral dosing of Bauhinia variegata L. bark powder at 6 gm/kg for 7
days and 3 gm/kg for another 7 days exhibited reduction of fibrous tissue in chronic mastitis.
Objective: The fibrolytic effect of one week oral dosing of Bauhinia purpurea L. bark powder was
studied in chronic mastitis with induced fibrosis as Bauhinia variegate L. is rarely available in plain
Method: Chronic mastitis with fibrosis was induced by intra-mammary inoculation of coagulase positive
Staphylococcus aureus in group III and IV. Groups I and III goats were injected with a single
dose of ceftriaxone at 20 mg/kg intravenously, whereas Group II and IV goats were orally administered
Bauhinia purpurea L. bark powder at 6 g/kg for 7 days with a single dose of ceftriaxone at 20
Results: The t1/2β of ceftriaxone with Bauhinia purpurea L. stem bark powder in chronic mastitis increased
significantly. Ceftizoxime was detected in plasma from 1 h to 48 h post dosing (pd) in Gr III
and from 1 h to 96 h pd in Gr IV, respectively.
Conclusion: Bark powder of Bauhinia purpurea L. at 6g/kg orally once daily increased the bioavailability
of ceftriaxone and or ceftizoxime in milk due to its fibrolytic effect which was not reported earlier.
Therefore, the Bauhinia purpurea L. bark powder having fibrolytic effect has the potential to reduce
the development of cancer.