Evaluation of Fibrolytic Effect of Bauhinia purpurea L.

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Author(s): Jeevan Ranjan Dash, Tapas Kumar Sar*, Rinku Buragohain, Indranil Samanta, Rahul Nanotkar.

Journal Name: Clinical Cancer Drugs

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Abstract:

Background: Mammary gland tissue (left half) revealed the presence of excess proliferation of fibrous tissue with disorganization of alveolar structures and the right half showed extensive fibrous tissue proliferation of mammary gland following intramammary inoculation of 2000 c.f.u. of Staphylococcus aureus. However, oral dosing of Bauhinia variegata L. bark powder at 6 gm/kg for 7 days and 3 gm/kg for another 7 days exhibited reduction of fibrous tissue in chronic mastitis.

Objective: The fibrolytic effect of one week oral dosing of Bauhinia purpurea L. bark powder was studied in chronic mastitis with induced fibrosis as Bauhinia variegate L. is rarely available in plain land.

Method: Chronic mastitis with fibrosis was induced by intra-mammary inoculation of coagulase positive Staphylococcus aureus in group III and IV. Groups I and III goats were injected with a single dose of ceftriaxone at 20 mg/kg intravenously, whereas Group II and IV goats were orally administered Bauhinia purpurea L. bark powder at 6 g/kg for 7 days with a single dose of ceftriaxone at 20 mg/kg intravenously.

Results: The t1/2β of ceftriaxone with Bauhinia purpurea L. stem bark powder in chronic mastitis increased significantly. Ceftizoxime was detected in plasma from 1 h to 48 h post dosing (pd) in Gr III and from 1 h to 96 h pd in Gr IV, respectively.

Conclusion: Bark powder of Bauhinia purpurea L. at 6g/kg orally once daily increased the bioavailability of ceftriaxone and or ceftizoxime in milk due to its fibrolytic effect which was not reported earlier. Therefore, the Bauhinia purpurea L. bark powder having fibrolytic effect has the potential to reduce the development of cancer.

Keywords: Bauhinia purpurea L., ceftizoxime, ceftriaxone, chronic mastitis, disposition study, fibrolytic effect.

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(E-pub Ahead of Print)
DOI: 10.2174/2212697X06666190131155256

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