Recent Synthetic Approaches and Biological Evaluations of Amino Hexahydroquinolines and Their Spirocyclic Structures

Author(s): Amr M. Abdelmoniem, Magda F. Mohamed, Doaa M. Abdelmoniem, Said A.S. Ghozlan, Ismail A. Abdelhamid*.

Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Volume 19 , Issue 7 , 2019

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Graphical Abstract:


Abstract:

In this review, the recent synthetic approaches of amino hexahydroquinolines and their spirocyclic structures were highlighted. The synthetic routes include, two-components, three-components or fourcomponents reactions. The two-component [3+3] atom combination reaction represents the simplest method. It involves Michael addition of the electron rich β-carbon of β-enaminones to the activated double bond of cinnamonitriles followed by cyclization to yield hexahydroquinoline compounds. The bioactivity profiles and SAR studies of these compounds were also reviewed with emphasis to the utility of these substances as antimicrobial, anticancer and antitubercular agents, as well as calcium channel modulators.

Keywords: Hexahydroquinolines, fused and spirocyclic derivatives, synthetic approaches, antimicrobial, anticancer, anti-tuberculosis activity, calcium channel modulators.

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