Background: In the herbal drug pharmaceutical industry, guggul is enjoying emergent
consumer acceptance around the world. In the Indian market, more than fifty formulations of guggul
have been introduced by well-known brands including Himalaya, Patanjali and Baidyanath Pharmaceuticals.
Basically, guggul is the gum resin from Commiphora wightii (syn. Commiphora Mukul). It
has been used to treat various ailments including obesity, osteoarthritis, arthritis, constipation, liver
disorders, inflammation, anemia, diabetes etc. Including medicinal properties, it is used as a good
binding agent and mixed in various herbal formulations.
Objectives: To review the major phytochemical, medicinal properties and analytical methods involved
in the detection of guggul by using the exhaustive bibliographic research by means of various
scientific engines and databases.
Conclusion: Guggul contained approximately 66 phytochemical including gallic acid, quercetin, and
guggulsterones E and Z. These phytochemicals have a wide range of pharmacological activities such
as antioxidant, antibacterial, antimutagenic, antivenom and antitumor. It has been noticed that the
mode of action of guggulsterone has not been fully explored. Pharmacology and toxicological studies
are very few. These works have shown huge literature gap, which is to be fulfilled through the detailed
in-vivo and in-vitro studies.