Resveratrol is a non-flavonoid polyphenol containing a terpenoid backbone. It has been intensively
studied because of its various promising biological properties, such as anticancer, antioxidant,
antibacterial, neuroprotective and anti-inflammatory activities. However, the medicinal application
of resveratrol is constrained by its poor bioavailability and stability. In the past decade, more attention
has been focused on making resveratrol derivatives to improve its pharmacological activities
and pharmacokinetics. This review covers the literature published over the past 15 years on synthetic
analogues of resveratrol. The emphasis is on the chemistry of new compounds and relevant biological
activities along with structure-activity relationship. This review aims to provide a scientific and reliable
basis for the development of resveratrol-based clinical drugs.
Keywords: Resveratrol, antioxidants, anticancer, anti-inflammatory, structure-activity relationship, roots of white hellebore.
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