Introduction: Cervical cancer is the most prevalent cancer in the world due to unusual
extension of cervical cell. Cervical cancer occurs due to exposure of HPV (Human papillomavirus).
According to WHO, it is the 4th most ordinary cancer in women. In 2018, approx 6.6% of
population was affected around the world and 570,000 new cases were reported. In low and
middle-income countries, 90% of cervical cancer deaths occur.
Methods: Despite various factors that cause cervical cancer are included exposure to HPV,
dysregulation of CASPASE enzyme, elevated expression of IAPs (Inhibitor apoptotic protein), E6
and E7 gene of HPV, inhibition of p53, BAK, p16 upregulation, CDK-inactivation causing cervical
cancer, role of VEGF, role of estrogen and its receptor in cervical cancer.
Results: Cervical cancer can be screened by Pep test. There are various therapies that can be used
to treat cervical cancer. As these therapies have various side effects, so the world is moving to
herbal formulations to treat cervical cancer.
Conclusion: In this study, we will discuss cervical cancer, its cause, symptoms, pathophysiology
and treatments. Early screening and detection can help in reducing the overall burden of cervical
cancer in the near future.