Mechanism and Treatment of Rituximab Resistance in Diffuse Large Bcell Lymphoma

Author(s): Linqing Zou, Guoqi Song, Siyu Gu, Lingling Kong, Shiqi Sun, Li Yang*, William C. Cho*.

Journal Name: Current Cancer Drug Targets

Volume 19 , Issue 9 , 2019

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Abstract:

Diffuse large B-cell lymphoma (DLBCL) is the most common subtype B non-Hodgkin lymphoma in adults. After rituximab being introduced to treat DLBCL, the current first-line treatment is R-CHOP regimen. This regimen greatly improves patient's prognosis, however, relapsed or refractory cases are commonly seen, mainly due to the resistance to rituximab. Although a large number of experiments have been conducted to investigate rituximab resistance, the exac mechanisms and solutions are still unclear. This review mainly explores the possible mechanisms oft rituximab resistance and current new effective treatments for rituximab resistance in DLBCL.

Keywords: Diffuse large B-cell lymphoma, CD20, rituximab resistance, biomarker, non-Hodgkin lymphoma, prognosis.

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VOLUME: 19
ISSUE: 9
Year: 2019
Page: [681 - 687]
Pages: 7
DOI: 10.2174/1568009619666190126125251
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