Abstract
Vitreomacular traction occurs due to incomplete or anomalous posterior vitreous detachment. Over time, the vitreous pulls anteriorly and causes retinal distortion and eventually reduced vision. Traditionally, vitreomacular traction was treated with vitrectomy surgery. In the past few years, there is a paradigm shift towards pharmacologic vitreolysis, which involves the intravitreal injection of enzymatic and non-enzymatic agents that facilitate posterior vitreous detachment. Many agents have been investigated and trialled including plasmin, microplasmin (Ocriplasmin), hyaluronidase, nattokinase, chondroitinase and dispase. This review will focus on the progress and current status in this research.
Keywords: Vitreous, vitreomacular traction, vitreomacular adhesion, macular hole, posterior vitreous detachment, pharmacological vitreolysis, ocriplasmin.
Current Pharmaceutical Design
Title:Pharmacotherapy of Vitreomacular Traction
Volume: 24 Issue: 41
Author(s): Ran Wan *, Thomas Hong, Yasser Tariq and Andrew Chang
Affiliation:
- Sydney Retina Clinic & Day Surgery, (Lvl 13) 187 Macquarie St, Sydney, NSW,Australia
Keywords: Vitreous, vitreomacular traction, vitreomacular adhesion, macular hole, posterior vitreous detachment, pharmacological vitreolysis, ocriplasmin.
Abstract: Vitreomacular traction occurs due to incomplete or anomalous posterior vitreous detachment. Over time, the vitreous pulls anteriorly and causes retinal distortion and eventually reduced vision. Traditionally, vitreomacular traction was treated with vitrectomy surgery. In the past few years, there is a paradigm shift towards pharmacologic vitreolysis, which involves the intravitreal injection of enzymatic and non-enzymatic agents that facilitate posterior vitreous detachment. Many agents have been investigated and trialled including plasmin, microplasmin (Ocriplasmin), hyaluronidase, nattokinase, chondroitinase and dispase. This review will focus on the progress and current status in this research.
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Cite this article as:
Wan Ran *, Hong Thomas , Tariq Yasser and Chang Andrew , Pharmacotherapy of Vitreomacular Traction, Current Pharmaceutical Design 2018; 24 (41) . https://dx.doi.org/10.2174/1381612825666190124102148
DOI https://dx.doi.org/10.2174/1381612825666190124102148 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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