Title:Pharmacotherapy of Vitreomacular Traction
VOLUME: 24 ISSUE: 41
Author(s):Ran Wan *, Thomas Hong, Yasser Tariq and Andrew Chang
Affiliation:Sydney Retina Clinic & Day Surgery, (Lvl 13) 187 Macquarie St, Sydney, NSW, Sydney Retina Clinic & Day Surgery, (Lvl 13) 187 Macquarie St, Sydney, NSW, Sydney Retina Clinic & Day Surgery, (Lvl 13) 187 Macquarie St, Sydney, NSW, Sydney Retina Clinic & Day Surgery, (Lvl 13) 187 Macquarie St, Sydney, NSW
Keywords:Vitreous, vitreomacular traction, vitreomacular adhesion, macular hole, posterior vitreous detachment, pharmacological
vitreolysis, ocriplasmin.
Abstract:Vitreomacular traction occurs due to incomplete or anomalous posterior vitreous detachment. Over
time, the vitreous pulls anteriorly and causes retinal distortion and eventually reduced vision. Traditionally, vitreomacular
traction was treated with vitrectomy surgery. In the past few years, there is a paradigm shift towards
pharmacologic vitreolysis, which involves the intravitreal injection of enzymatic and non-enzymatic agents that
facilitate posterior vitreous detachment. Many agents have been investigated and trialled including plasmin, microplasmin
(Ocriplasmin), hyaluronidase, nattokinase, chondroitinase and dispase. This review will focus on the
progress and current status in this research.
