A Review of Preclinical Experiments Toward Targeting M2 Macrophages in Prostate Cancer

Author(s): Farhad Seif, Laleh Sharifi, Majid Khoshmirsafa, Yasaman Mojibi, Monireh Mohsenzadegan*.

Journal Name: Current Drug Targets

Volume 20 , Issue 7 , 2019

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Abstract:

Prostate cancer is malignant cancer leading to high mortality in the male population. The existence of suppressive cells referred to as tumor-associated macrophages (TAM) is a major obstacle in prostate cancer immunotherapy. TAMs contribute to the immunosuppressive microenvironment that promotes tumor growth and metastasis. In fact, they are main regulators of the complicated interactions between tumor and surrounding microenvironment. M2 macrophages, as a type of TAMs, are involved in the growth and progression of prostate cancer. Recently, they have gained remarkable importance as therapeutic candidates for solid tumors. In this review, we will discuss the roles of M2 macrophages and worth of their potential targeting in prostate cancer treatment. In the following, we will introduce important factors resulting in M2 macrophage promotion and also experimental therapeutic agents that may cause the inhibition of prostate cancer tumor growth.

Keywords: Prostate cancer, tumor-associated macrophage, M1/M2 macrophage, solid tumors, experimental therapeutic, suppressive cells.

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Article Details

VOLUME: 20
ISSUE: 7
Year: 2019
Page: [789 - 798]
Pages: 10
DOI: 10.2174/1389450120666190123141553
Price: $58

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