Green Synthesis, in-vitro Antimicrobial Evaluation, Docking, and SAR Studies of Potent Quinoline-4-Carboxylic Acids

Author(s): Badvel Pallavi , Rajnish Prakash Singh , Prabhat Nath Jha , Subhash Chander , Sankaranarayanan Murugesan , Prachi Sharma , Paritosh Shukla* .

Journal Name: Letters in Organic Chemistry

Volume 16 , Issue 11 , 2019

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Abstract:

The paper describes the synthesis of quinoline-4-carboxylic acid derivatives employing completely green methods such as the use of water as solvent and of microwave irradiation for heating. The prepared molecules were examined for bactericidal and antifungal behavior and two of the tested compounds showed reasonably good antimicrobial activity. The biological activity results were further corroborated by fluorescence microscopy and by evaluating their time-dependent bactericidal behavior. Two of the most potent compounds were then subjected to docking against DNA gyrase protein (PDB ID: 2XCT) showing possible interactions responsible for the potency of these compounds. Also, an SAR analysis was proposed based on the results obtained.

Keywords: Quinoline-4-carboxylic acids, green chemistry, microwave irradiation, in-vitro, in-silico studies, SAR analysis.

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Article Details

VOLUME: 16
ISSUE: 11
Year: 2019
Page: [874 - 883]
Pages: 10
DOI: 10.2174/1570178616666190123121506
Price: $58

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