Biological Activities of Artemisinin Derivatives Beyond Malaria

(E-pub Abstract Ahead of Print)

Author(s): Xiaoyan Liu, Jianguo Cao, Guozheng Huang*, Qingjie Zhao*, Jingshan Shen.

Journal Name: Current Topics in Medicinal Chemistry

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Artemisinin is isolated from Artemisia annua L with peroxide-containing sesquiterpene lactone structure. Because of its unique structural characteristics and promising anticancer, antivirus activities, it has recently received increasing attention. The aim of this review is to summarize recent discoveries of artemisinin's novel derivatives with new pharmaceutical effects beyond malaria with a focus on its antitumor and antivirus activity, as well as potential results of combination therapy with other clinical drugs.

Keywords: Artemisinin, Artemisinin derivatives, Antiviral activity, Anticancer activity, Dimer, Trimer.

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Article Details

(E-pub Abstract Ahead of Print)
DOI: 10.2174/1568026619666190122144217
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