Flavonoid-Enriched Extract from Desert Plant Warionia saharae Improves Glucose and Cholesterol Levels in Diabetic Rats

Author(s): Mohammed Ajebli, Mohamed Eddouks*.

Journal Name: Cardiovascular & Hematological Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Cardiovascular & Hematological Agents)

Volume 17 , Issue 1 , 2019

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Graphical Abstract:


Abstract:

Background and Objective: Warionia saharae Benth and Coss, is a medicinal plant used for its anti-diabetic properties in Morocco. This study was designed to examine the effect of the Flavonoid- Enriched Extract (FEE) obtained from Warionia saharae (W. saharae) on glucose and lipid metabolism in normal and streptozotocin (STZ)-induced diabetic rats.

Methods: Acute (6 h) and sub-chronic (15 days) oral administration of FEE (10 mg/kg) was used to assess the glucose and lipid-lowering activity in normal and diabetic rats. Furthermore, glucose test tolerance, liver histopathological examination and in vitro antioxidant activity of FEE were carried out in this study.

Results: Results indicated that FEE was able to exert antihyperglycemic activity. Additionally, FEE improved histopathological status of liver and pancreas in diabetic rats and possessed antioxidant activity.

Conclusion: In conclusion, the present investigation revealed that FEE had potent antidiabetic effect in diabetic rats.

Keywords: Antioxidant, diabetes, flavonoid-enriched extract, histopathology, lipid profile, Warionia saharae.

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Article Details

VOLUME: 17
ISSUE: 1
Year: 2019
Page: [28 - 39]
Pages: 12
DOI: 10.2174/1871525717666190121143934

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