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Current Protein & Peptide Science

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ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

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Review Article

Adipocytes-released Peptides Involved in the Control of Gastrointestinal Motility

Author(s): Eglantina Idrizaj, Rachele Garella, Roberta Squecco and Maria Caterina Baccari*

Volume 20, Issue 6, 2019

Page: [614 - 629] Pages: 16

DOI: 10.2174/1389203720666190121115356

Price: $65

Abstract

The present review focuses on adipocytes-released peptides known to be involved in the control of gastrointestinal motility, acting both centrally and peripherally. Thus, four peptides have been taken into account: leptin, adiponectin, nesfatin-1, and apelin. The discussion of the related physiological or pathophysiological roles, based on the most recent findings, is intended to underlie the close interactions among adipose tissue, central nervous system, and gastrointestinal tract. The better understanding of this complex network, as gastrointestinal motor responses represent peripheral signals involved in the regulation of food intake through the gut-brain axis, may also furnish a cue for the development of either novel therapeutic approaches in the treatment of obesity and eating disorders or potential diagnostic tools.

Keywords: Adiponectin, apelin, gastrointestinal motility, leptin, nesfatin-1, smooth muscle.

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