Selective α,α-Dibromination of Arylethanones with Copper(II) Bromide

Author(s): Jitander K. Kapoor, Loveena Arora*, Om Prakash.

Journal Name: Letters in Organic Chemistry

Volume 16 , Issue 9 , 2019

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Graphical Abstract:


Abstract:

Various arylethanones including electron-rich aromatic ketones such as o-hydroxyacetophenone and its p-isomer underwent selective side-chain α,α-dibromination using a heterogeneous system consisting of four molar equivalents of copper(II) bromide in chloroform-ethyl acetate under reflux. This study provides the cleanest method for the selective synthesis of several synthetically useful α,α-dibromoketones which are otherwise difficult to prepare.

Keywords: o/p-Hydroxyacetophenone, heterogeneous system, side-chain dibromination, arylethanones, copper(II) bromide, bromoketone.

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Article Details

VOLUME: 16
ISSUE: 9
Year: 2019
Page: [700 - 704]
Pages: 5
DOI: 10.2174/1570178616666190118152325
Price: $65

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