On account of the advantages of transdermal delivery and the application situation of transcutaneous
technology in transdermal delivery, the article critically comments on nanosystems as permeation
enhancement model. Nanosystems possess great potential for transcutaneous drug delivery. This
review focuses on recent advances in lipid-based nanocarriers, including liposome, transfersomes,
ethosomes, nanoemulsions, solid lipid nanoparticles, nanostructured lipid carriers and combination
application of the lipid-based nanocarriers with microneedle, iontophoresis, electroporation and sonophoresis
in the field for the development of the transdermal drug delivery system.
We attempted to give an overview of lipid-based nanocarriers with the aim to improve transdermal and
dermal drug delivery. A special focus is given to the nanocarrier composition, characteristic and interaction
mechanisms through the skin. Recent combination applications of lipid-based nanocarriers with
the physical penetration technologydemonstrate the superiority of the combined use of nanocarriers and
physical methods in drug penetration enhancement compared to their single use. In the future, lipidbased
nanocarriers will play a greater role in the field of transdermal and dermal drug delivery.