Medicated foams and film forming systems are dosage forms formulated to undergo a controlled
metamorphosis when applied on the skin. Indeed, due to the presence of propellant or a particular
air-spray foam pump, a liquid can generate foam when applied on the stratum corneum, or a liquid or
conventional dosage form can form on the skin a continuous film as a consequence of the solvent
evaporation. Thanks to these controlled modifications, the drug thermodynamic activity increases favoring
the skin penetration and, therefore, the bioavailability with respect to conventional semi-solid and
liquid dosage forms. Furthermore, the available clinical data also evidence that these dosage forms improve
the patient’s compliance. The main formulative aspects of medicated foams and film forming
systems are reviewed with the aim to underline the possible advantages in terms of biopharmaceutical
performances and patient’s adherence.
Keywords: cutaneous administration, film forming system, medicated foam, skin permeation, substantivity, supersaturation.
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