Background: Interleukin-17A (IL-17A) is a pro-inflammatory cytokine that has gained a lot
of attention because of its involvement in respiratory diseases. Interleukin-17 cytokine family includes
six members, out of which, IL-17A participates towards the immune responses in allergy and
inflammation. It also modulates the progression of respiratory disorders.
Objective: The present review is an insight into the involvement and contributions of the proinflammatory
cytokine IL-17A in chronic respiratory diseases like idiopathic pulmonary fibrosis (IPF),
chronic obstructive pulmonary distress (COPD), asthma, pneumonia, obliterative bronchiolitis, lung
cancer and many others.
Conclusion: IL-17A is a major regulator of inflammatory responses. In all the mentioned diseases, IL-
17A plays a prime role in inducing the diseases, whereas the lack of this pro-inflammatory cytokine
reduces the severity of respective respiratory diseases. Thereby, this review suggests IL-17A as an
instrumental target in chronic respiratory diseases.