Natural tyrosinase inhibitors: Role of herbals in the treatment of hyperpigmentary disorders

(E-pub Abstract Ahead of Print)

Author(s): Kamal Uddin Zaidi*, Sharique A Ali, Ayesha Ali, Ishrat Naaz.

Journal Name: Mini-Reviews in Medicinal Chemistry

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Cutaneous pigmentation plays critical role in determining the color of skin along with photo protection of skin from dreadful effects of ultraviolet radiations. However, uncontrolled led to onset of serious aesthetic problems of hyperpigmentations such as melasma, senile lentigines and freckles. Because of the visible nature of dermatologic diseases, they have a considerable psychosomatic effect on affected patients. Tyrosinase inhibitors are molecules that interrelate in some way with the enzyme to prevent it from working in the normal manner. Past many decades witnessed the quest for the development of natural tyrosinase inhibitors due to imperative role played by tyrosinase in the process of melanogenesis and fungi or fruit enzymatic browning. Mechanism of pigmentation is characterized by the intact process of the synthesis of specialized black pigment within melanosomes. Melanin is manufactured by a cascade of enzymatic and chemical reactions. In this article judgment tyrosinase inhibitors recently exposed from natural sources, their regulatory pathways and inhibitory mechanistic actions of tyrosinase are argued.

Keywords: Alkaloids, Tyrosinase, Herbal, Pigmentation, Enzyme inhibitors.

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(E-pub Abstract Ahead of Print)
DOI: 10.2174/1389557519666190116101039
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