Objective: Ten racemic 3,4-dihydropyrimidin-2(1H)-ones and 3,4-dihydropyrimidin-
2(1H)-thiones were separated by liquid chromatography on Chiralcel®OD-H column containing cellulose
Methods: The enantioseparation was carried out using Chiralcel®OD-H polysaccharide-type chiral
stationary phase to resolve such enantiomers under normal-phase mode.
Results: Complete separations of the 3,4-dihydropyrimidin-2(1H)-ones and 3,4-dihydropyrimidin-
2(1H)-thiones derivatives with good resolution (RS= 1.04-2.80) were achieved within a short time
Conclusion: An optimal baseline separation (Rs> 1.5) was achieved using Chiralcel®OD-H under
normal-phase mode. Structure-retention relationships have also been discussed.
Keywords: 3, 4-dihydropyrimidin-2(1H)-ones, 3, 4-dihydropyrimidin-2(1H)-thiones, Chiralcel®OD-H, tris(3, 5-dimethylphenylcarbamate),
chiral separation, HPLC.
Rights & PermissionsPrintExport