Self-microemulsion technology for water insoluble drug delivery

(E-pub Abstract Ahead of Print)

Author(s): Beibei Yan, Yu Gu, Juan Zhao, Yangyang Liu, Lulu Wang, Yancai Wang*.

Journal Name: Current Nanoscience

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Abstract:

According to the drug discovery, approximately 40% of the new chemical entities show poor bioavailability due to their low aqueous solubility. In order to increase the solubility of the drugs, self-microemulsifying drug delivery systems (SMEDDS) is considered as an ideal technology for enhancing the permeability of poorly soluble drugs in GI membranes. The SMEDDS are also generally used to enhance the oral bioavailability of the hydrophobic drugs. At present, most of the self-microemulsion drugs are liquid dosage forms, which could be caused some disadvantages, such as the low bioavailability of the traditional liquid SMEDDS. Therefore, solid self-microemulsifying drug delivery systems (S-SMEDDS) has been emergence widely in recent years, which was prepared by solidifying a semi-solid or liquid self-emulsifying (SE) ingredient into a powder in order to improve stability, treatment and patient compliance. The article gives a comprehensive introduce of the study of SMEDDS which could effectively tackle the problem of the water insoluble drug, especially the development of solidification technology of SMEDDS. Finally, the present challenges and the prospects in this field were also discussed.

Keywords: Water insoluble drug, self-microemulsifying, drug delivery, evaluation index, solidification technology, stability, bioavailability

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Article Details

(E-pub Abstract Ahead of Print)
DOI: 10.2174/1573413715666190112122107
Price: $95