Objective: We aimed to investigate the etiology and prevalence of anemia in patients with
diabetic foot ulcers and the relationship between both microvascular complications and related
conditions and anemia.
Methods: We retrospectively collected and evaluated the data of 225 patients with diabetic foot ulcer
followed at our clinic. The demographic characteristics of the patients were analyzed. Complete blood
count for those with anemia, serum iron, iron-binding capacity, ferritin, transferrin saturation index,
vitamin B12, folic acid and thin blood film were performed. The diabetic microvascular complications
and related conditions such as osteomyelitis, peripheral artery disease, and amputations were also determined.
IBM SPSS Statistics Version 20.0 package software was used for the statistical analysis of
Results: Of 225 patients were 67 (29%) female and 158 (70.2%) male. The mean age of the patients
was 62 ± 10.5 years (30-87). Duration of diabetes was 16.2 ± 6.7 years (2-31). Of the 225 patients, 41
had hypertension, 14 had chronic kidney failure, and 34 had coronary artery disease. Anemia was
found in 192 (85.3%) of the 225 patients. Of 192, 126 (56%) had iron deficiency anemia, 50 had folate-
deficiency anemia, and the remaining 16 had anemia of chronic disease. Iron deficiency anemia
was significantly found to be higher in women. There was no significant difference between patients
with and without anemia in terms of diabetic microvascular complications (neuropathy, retinopathy,
nephropathy) and the related conditions.
Conclusion: We have found that the most common cause of anemia was iron deficiency anemia.
However, in our study, the prevalences of microvascular complications did not vary between patients
with and without anemia. On the other hand, since all of our patients are having DFU and the high
rates of microvascular complications and correlation with the presence of anemia could not be clearly