Triple Antithrombotic Therapy vs. Double Antithrombotic Therapy: One Scenario, 8 Questions, Many Conclusions

Author(s): Elio Aloia*, Paolo Orselli, Carlotta Sciaccaluga.

Journal Name: Current Cardiology Reviews

Volume 15 , Issue 3 , 2019

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Graphical Abstract:


In patients with atrial fibrillation undergoing percutaneous coronary intervention with the placement of stents, a triple antithrombotic therapy is empirically established, which consists of a combination of dual antithrombotic therapy (aspirin plus a P2Y12 inhibitor) and an oral anticoagulant agent. This choice is guided by the desirable result of reducing cerebrovascular and coronary ischemic events. However, there is an unwelcome outcome: an increased incidence of bleeding. On this matter, in 2018, a North American Perspective Update was published, about a year later it was followed by the publication of the European focus update on the dual antiplatelet therapy. After analysing the main differences between these two consensus documents, this review aims at examining the major studies on which they are based on, as a starting point to define the foundation of new trials that can help shed light on this prominent topic.

Keywords: Triple antithrombotic therapy, dual antithrombotic therapy, atrial fibrillation, Percutaneous Coronary Intervention (PCI), NOAC, OAC.

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Article Details

Year: 2019
Page: [219 - 223]
Pages: 5
DOI: 10.2174/1573403X15666190111095438
Price: $58

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