Role of Regulatory Oncogenic or Tumor Suppressor miRNAs of PI3K/AKT Signaling Axis in the Pathogenesis of Colorectal Cancer

Author(s): Atena Soleimani, Farzad Rahmani, Gordon A. Ferns, Mikhail Ryzhikov, Amir Avan*, Seyed Mahdi Hassanian*.

Journal Name: Current Pharmaceutical Design

Volume 24 , Issue 39 , 2018

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Abstract:

Colorectal cancer (CRC) is the leading cause of cancer death worldwide and its incidence is increasing. In most patients with CRC, the PI3K/AKT signaling axis is over-activated. Regulatory oncogenic or tumor suppressor microRNAs (miRNAs) for PI3K/AKT signaling regulate cell proliferation, migration, invasion, angiogenesis, as well as resistance to chemo-/radio-therapy in colorectal cancer tumor tissues. Thus, regulatory miRNAs of PI3K/AKT/mTOR signaling represent novel biomarkers for new patient diagnosis and obtaining clinically invaluable information from post-treatment CRC patients for improving therapeutic strategies. This review summarizes the current knowledge of miRNAs’ regulatory roles of PI3K/AKT signaling in CRC pathogenesis.

Keywords: PI3K/AKT signaling, microrna, colorectal cancer, tumor suppressor, microRNAs, CRC pathogenesis.

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Article Details

VOLUME: 24
ISSUE: 39
Year: 2018
Page: [4605 - 4610]
Pages: 6
DOI: 10.2174/1381612825666190110151957
Price: $58

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