Natural cyclic peptides are conformationally constrained notable biomolecules
and reveal several drug-like properties such as high binding affinity, metabolic stability,
target selectivity, bioavailability, low toxicity and flexibility. They have attracted a lot of
attention as alternative sources of new drugs to traditional small molecules in drug discovery.
Compared to classical medicines, cyclic peptides with a novel mechanism of action
are attractive for their potential therapeutic applications particularly for cancer therapy and
several diseases caused by resistant and non-resistant bacteria, virus, and fungi. Herein,
we provide an overview of the naturally occurring biologically active cyclic peptide therapeutic
landscape, including promising candidates, which are under trial in different stages
for future and/or clinically used drugs against different diseases. This will certainly be an
essential resource for upcoming and existing researchers and scientists within industry and
academia in medicinal, bioorganic, and natural product chemistry.
Keywords: Natural products, cyclic peptides, clinical drugs, antifungal, antibacterial, anticancer, anti-HIV.
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