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Current Drug Delivery

Editor-in-Chief

ISSN (Print): 1567-2018
ISSN (Online): 1875-5704

Research Article

The Effect of Focused Ultrasound on Magnetic Polyelectrolyte Capsules Loaded with Dye When Suspended in Tissue-Mimicking Gel

Author(s): Carmen Stavarache*, Mircea Vinatoru and Timothy Mason

Volume 16, Issue 4, 2019

Page: [355 - 363] Pages: 9

DOI: 10.2174/1567201816666190103121313

Abstract

Background: Capsules containing a dye were prepared by the LbL method with iron oxide nanoparticles (50 nm) in different layers of the shell.

Method: The capsules were dispersed in a gel and subjected to focused ultrasonic irradiation at three different powers and exposure times.

Result: It was found that the inclusion of iron oxide magnetic nanoparticles in any of the polyelectrolyte shells (4, 6, 8 and 10) strengthened the capsules with respect to capsules without nanoparticles. Incorporation of nanoparticles in shell 8 provided the most resistance to fragmentation under focused ultrasonic irradiation. The relative degree of capsule stability is dependent on both the power of the ultrasound and the exposure time.

Conclusion: The presence of iron oxide nanoparticles not only conferred more resistance to fragmentation but also provided a route to protein labelled dye release through sonoporation that was not present for capsules without nanoparticles.

Keywords: Microencapsulation, nanoparticles, ultrasound, controlled release, targeted drug delivery, fragmentation.

Graphical Abstract
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