The Effect of Focused Ultrasound on Magnetic Polyelectrolyte Capsules Loaded with Dye When Suspended in Tissue-Mimicking Gel

Author(s): Carmen Stavarache*, Mircea Vinatoru, Timothy Mason.

Journal Name: Current Drug Delivery

Volume 16 , Issue 4 , 2019

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Graphical Abstract:


Abstract:

Background: Capsules containing a dye were prepared by the LbL method with iron oxide nanoparticles (50 nm) in different layers of the shell.

Method: The capsules were dispersed in a gel and subjected to focused ultrasonic irradiation at three different powers and exposure times.

Result: It was found that the inclusion of iron oxide magnetic nanoparticles in any of the polyelectrolyte shells (4, 6, 8 and 10) strengthened the capsules with respect to capsules without nanoparticles. Incorporation of nanoparticles in shell 8 provided the most resistance to fragmentation under focused ultrasonic irradiation. The relative degree of capsule stability is dependent on both the power of the ultrasound and the exposure time.

Conclusion: The presence of iron oxide nanoparticles not only conferred more resistance to fragmentation but also provided a route to protein labelled dye release through sonoporation that was not present for capsules without nanoparticles.

Keywords: Microencapsulation, nanoparticles, ultrasound, controlled release, targeted drug delivery, fragmentation.

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Article Details

VOLUME: 16
ISSUE: 4
Year: 2019
Page: [355 - 363]
Pages: 9
DOI: 10.2174/1567201816666190103121313

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