The Effect of Focused Ultrasound on Magnetic Polyelectrolyte Capsules Loaded with Dye When Suspended in Tissue-Mimicking Gel

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Author(s): Carmen Stavarache*, Mircea Vinatoru, Timothy Mason.

Journal Name: Current Drug Delivery

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Capsules containing a dye were prepared by the LbL method with iron oxide nanoparticles (50 nm) in different layers of the shell. The capsules were dispersed in a gel and subjected to focused ultrasonic irradiation at three different powers and exposure times. It was found that the inclusion of iron oxide magnetic nanoparticles in any of the polyelectrolyte shells (4, 6, 8 and 10) strengthened the capsules with respect to capsules without nanoparticles. Incorporation of nanoparticles in shell 8 provided the most resistance to fragmentation under focused ultrasonic irradiation. The relative degree of capsule stability depended on both the power of the ultrasound and the exposure time. The presence of iron oxide nanoparticles not only conferred more resistance to fragmentation but also provided a route to protein labelled dye release through sonoporation that was not present for capsules without nanoparticles.

Keywords: microencapsulation, nanoparticles, ultrasound, controlled release, targeted drug delivery,

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(E-pub Ahead of Print)
DOI: 10.2174/1567201816666190103121313
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