Background: Esophageal cancer (EC) is a common digestive system tumor, characterized
by high invasion, apparent lethality, and poor prognosis. Direct diffusion is the major metastatic
mechanism of early EC, whereas advanced EC is spread mainly by lymphatic metastasis, but also can
be transferred to the liver, lungs, bones, and so on, by hematogenous metastasis. The incidence of bone
metastasis in esophageal cancer is low, and maxillary metastasis of EC is more rare.
Objective: To explore the differential diagnosis in ECMM, the rare metastasis of EC, and the possible
mechanisms and predictors of bone metastasis.
Methods: The clinical materials of a male patient with maxillary metastasis of esophageal cancer
(ECMM) were analyzed. Then, the possible mechanism of the ECMM was discussed.
Conclusion: ECMM may belong to the hematogenous metastasis. The early detection of rare sites of
metastasis of EC should be prioritized in tumor marker detection, imaging, pathology, and other