Antimicrobial resistance is a global health problem with strong social and economic
impacts. The development of new antimicrobial agents is considered an urgent challenge. In this
regard, Antimicrobial Peptides (AMPs) appear to be novel candidates to overcome this problem.
The mechanism of action of AMPs involves intracellular targets and membrane disruption. Although
the exact mechanism of action of AMPs remains controversial, most AMPs act through
membrane disruption of the target cell. Several strategies have been used to improve AMP activity,
such as peptide dimerization. In this review, we focus on AMP dimerization, showing many examples
of dimerized peptides and their effects on biological activity. Although more studies are necessary
to elucidate the relationship between peptide properties and the dimerization effect on antimicrobial
activity, dimerization constitutes a promising strategy to improve the effectiveness of
Keywords: Peptide, antimicrobial, dimerization, mechanism of action, membrane, Antimicrobial Peptides (AMPs).
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