Backgroud: The present study aimed to investigate the association between immune cells
and gestational diabetes mellitus (GDM) and identify a reasonable predictor of insulin resistance in
women with GDM.
Objective: The clinical and biochemical characteristics of 124 women with GDM and 168 healthy
pregnant women were compared.
Methods: The percentage of immune cells in the blood of the subjects was analyzed by flow cytometry.
Pearson’s correlation analysis revealed the correlation between the percentage of B lymphocytes
and insulin resistance. A cutoff point was determined for the percentage of B lymphocytes, based on
insulin resistance, using receiver operating characteristic (ROC) curves.
Results: Compared to the healthy pregnant women, the percentages of B lymphocytes and IgA produced
by B-cells were significantly different in women with GDM. The percentage of B lymphocytes
was positively related to insulin resistance.The number of 14.05% of B lymphocytes was an optimal
cutoff point that predicted the insulin resistance in women with GDM.
Conclusion: The percentage of B lymphocytes was positively associated with insulin resistance, and
hence, might serve as an appropriate predictor of insulin resistance in women with GDM.