Probucol Self-Emulsified Drug Delivery System: Stability Testing and Bioavailability Assessment in Human Volunteers

(E-pub Ahead of Print)

Author(s): Abdelazim Zaghloul*, Ahmed Lila, Fathy Abd-Allah, Aly Nada.

Journal Name: Current Drug Delivery

Become EABM
Become Reviewer

Abstract:

Self-emulsifying drug delivery system (SEDDS), if taken orally, is expected to self-emulsify in GIT and improve the absorption and bioavailability. Probucol (PB) is a highly lipophilic compound with very low and variable bioavailability. The objectives of this study were to examine the stability and conduct bioavailability of the prepared probucol self-emulsified drug delivery system (PBSEDDS) in human volunteers. The methods included preparation of different PBSEDDS using soybean oil (solvent), Labrafil M1944CS (surfactant) and Capmul MCM-C8 (co-surfactant). The formulations were characterized in vitro for spontaneity of emulsification, droplet size, turbidity and dissolution in water after packing in HPMC capsules. The optimized formulations were evaluated for stability at different storage temperatures and human bioavailability compared with the drug dissolved in soybean oil (reference). The results showed that formulations (F1-F4) were stable if stored at 20 oC. The mean (n=3) pharmacokinetic parameters for stable formulations were: The Cmax, 1070.76, 883.16, 2876.43, 3513.46 and 1047.37 ng/ml; the Tmax, 7.93, 7.33, 3.96, 3.67 and 4.67 hr.; the AUC (0-t), 41043.41, 37763.23, 75006.26, 46731.36 and 26966.43 ng.hr/ml for F1, F2, F3, F4 and reference, respectively. The percentage relative bioavailability was in this order: F3

Keywords: Probucol, Self-Emulsified Drug-Delivery System (SEDDS), Stability, Human Bioavailability

Rights & PermissionsPrintExport Cite as


Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1567201816666181227111912
Price: $95