In the recent years, an increasing attention has been given to the biological activities exerted
by organoselenium compounds. In 1984, Sies reported for the first time the ability of ebselen to
mimic the activity of glutathione peroxidase. From this milestone, several studies reported the pharmacological
properties of selenium-containing compounds including their exploitation as antimicrobials.
In this context, this minireview presents the most recent examples of seleno derivatives endowed
with antimicrobial activities while discussing the most interesting and recent synthetic procedures
used to obtain these compounds.
Keywords: Biofilm, diselenides, gram-negative bacteria, gram-positive bacteria, selenium, benzoisoselenazolones.
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