Objective: The objective of the present studies was to develop and evaluate curcumin loaded
NLCs for management of childhood dermatitis by exploiting its antimicrobial and anti-infective properties
and increasing its skin deposition.
Materials & Methods: The screened lipidic excipients (on solubility basis) were used to formulate NLC
dispersion by solvent injection technique and process variables were optimized. Central composite design
was employed to study the effect of surfactant, total lipid and ratio of solid lipid to liquid lipid on dependent
variables such as particle size, zeta potential, % entrapment efficiency and time for 80% drug release.
Statistical model indicated that higher surfactant concentrations, lower lipid concentrations, reducing the
solid lipid content minimized the particle size, maximized the % entrapment efficiency and optimized time
for 80% drug release, while it had an inverse effect on zeta potential. The TEM of NLC dispersions elucidated
its sphericity. Curcumin NLCs were incorporated into carbopol 934 P based gel and characterized
for morphological and rheological properties, drug release, skin permeation and retention study, skin irritancy,
in vitro microbial activity and stability.
Results: The optimized formulations exhibited satisfactory physicochemical properties and followed Higuchi
kinetic model. The NLC dispersion when incorporated into gel, was stable and nonirritating. Antimicrobial
study against S.aureus showed larger zone of inhibition with developed formulation.
Conclusion: The developed curcumin NLC gel exhibited potential in management of childhood dermatitis
by virtue of sustained drug release, increase skin deposition and efficient antimicrobial action.